The main focus of my research is on pharmaceutical policy, including the effects of direct-to-consumer advertising of prescription drugs and physician-directed promotion on prescribing and medicine use decisions. I also carry out systematic reviews of the effectiveness and safety of new drugs with UBC’s Therapeutics Initiative, and contribute to the Therapeutics Initiative’s educational activities and independent bulletin, the Therapeutics Letter, available at http://www.ti.ubc.ca/TherapeuticsLetter.
Current Graduate Students
Janet Currie. PhD Student, Interdisciplinary Studies, UBC. Improving the transparency, safety and effectiveness of off-label prescribing. Supervisor.
Teresa Alves. PhD in Pharmaceutical Policy. Department of Pharmacy, Utrecht University. Disease-oriented pharmaceutical advertising. Co-promoter.
Tarita Miller. MSc Student. Department of Anesthesiology, Pharmacology & Therapeutics, UBC. Incretin Mimetics and Risk of Acute Renal Failure. Supervisory Committee Member
Roojin Habibi. MSc Student. Global Health, McMaser University. Does the information in promotions by pharmaceutical sales representatives vary by level of clinical evidence and national policy? Supervisory Committee Member.
Hanley G, Mintzes B. Patterns of psychotropic medicine use in pregnancy in the United States from 2006 to 2011 among women with private insurance. BMC Pregnancy and Childbirth 2014; 14: 242
Nguyen CT, MacEntee MI, Mintzes B, Perry TL. Information for Physicians and Pharmacists about Drugs that Might Cause Dry Mouth: A Study of Monographs and Published Literature. Drugs Aging 2014; 31: 55-65
Mintzes B, Medication Safety: Opening up the black box. BMJ Qual Saf 2013; 22: 72-74
Schnier A, Lexchin J, Mintzes B, Jutel A, Holloway K. Too few, too weak: conflict of interest policies at Canadian Medical Schools. PLoS ONE 2013; 8 (7): e68633
Mintzes B, Lexchin J, Sutherland J, Beaulieu M-D, Wilkes M, Durrieu G, Reynolds E. Pharmaceutical Sales Representatives and Patient Safety: A comparative prospective study of information quality in Canada, France and the United States. J Gen Intern Med. 2013; 28(10): 1368–1375.
Fortin P, Mintzes B. Innes M. A Systematic Review of Intravitreal Bevacizumab for the Treatment of Diabetic Macular Edema. CADTH Technology Overviews 2013; 3(1) e3103
Mintzes B. Evidence-based medicine: strengths and limitations. Australian Prescriber 2013; 36 (S2): 17-21
Mintzes B. A leap of faith in antidepressant treatment? JAMA Psychiatry. 2013;70(12):1373. doi:10.1001/jamapsychiatry.2013.2114.
Mintzes B. New UK guidance on industry-health professional collaboration. BMJ 2012 JUN 14;344:e3952.
Vitry A, Mintzes B. Disease mongering and low testosterone in men: the tale of two regulatory failures. Medical Journal of Australia 2012; 196(10): 619-621
Mintzes B. Advertising of prescription-only medicines to the public: does evidence of benefit counterbalance harm? Annual Reviews of Public Health 2012; 33: 259-277
Daw JR, Mintzes B, Law MR, Hanley GE, Morgan S. Prescription drug use in pregnancy: a population based study in British Columbia, Canada (2001-2006). Clinical Therapeutics, 2011. doi:10.1016/j.clinthera.2011.11.025
Mintzes B. Regulation of formula advertising in The Philippines and promotion and protection of breastfeeding: A Commentary on Sobel, Iellamo, Raya, Padilla, Olivé and Nyunt-U. Social Science and Medicine 2011; 73: 1449-1451
Law MR, Mintzes B, Morgan SG. The sources and popularity of online drug information: an analysis of top search engine results and web page views. Annals of Pharmacotherapy 2011; 45 (3):350-356.
Mintzes B, Fortin P, Wright JM. Antidépresseurs et grossesse. Les inhibiteurs spécifique de la recapture de la sérotonine. Médecine 2010; 6 (6): 255-257
Healy D, Mangin D, Mintzes D. The ethics of randomized placebo controlled trials of antidepressants with pregnant women. International Journal of Risk and Safety in Medicine 2010; 22: 7-16.
Current research activities include ‘Pharmaceutical Sales Representatives and Patient Safety’, a study of the extent to which sales representatives are providing safety-related information on promoted drugs to family physicians. This CIHR-funded study compares information provision in three regulatory environments: in Canada, the U.S. and France.
A second study uses administrative data to examine patterns of use of psychotropic medicines in British Columbia, and to assess two neonatal health outcomes which have been associated with SSRI antidepressant use but for which evidence is either contradictory or limited: persistent pulmonary hypertension of the newborn, and autism spectrum disorders in children with prenatal exposure.
Another area of work is on model curriculum development on conflicts of interest and interactions with the industry for medical and pharmacy students. This project was co-sponsored by the World Health Organization and an NGO, Health Action International, and is ongoing.