Programme Head, CIHR Canadian HIV Trials Network
I received my training in clinical epidemiology at McMaster. I have spent many years involved in clinical trials in diverse areas. My primary focus is on clinical trial methodology and clinical trials in HIV/AIDS. I have a variety of other interests including the use of quality of life instruments in clinical trials. I also have particular content interest and experience in trials in the following areas: cardiovascular, renal, intensive care, emergency medicine, neonatology and health promotion.
Amy Slogrove PhD
Mathew Wiens, PhD
Caren Rose PhD
Aaron Gelfund MSc
Russell J , Singer J, et al for the VASST Investigators. Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock. NEJM 2008;358 (9): 877-887.
Walmsley , Singer J, et al for CTN 164 Study Group. A Prospective Randomized Controlled Trial of Structured Treatment Interruption in HIV-Infected Patients Failing Highly Active Antiretroviral Therapy. JAIDS 2007;45(4): 418-425
Magee LA, Singer J, et al, for the CHIPS Pilot Trial Collaborative Group. Control of Hypertension In Pregnancy Study. British Journal of Obstetrics and Gynaecology 2007:770-e20
Konduri GG, Singer J, et al and the Neonatal Inhaled Nitric Oxide Study Group. Early Inhaled Nitric Oxide Therapy for Term and Near Term Newborn Infants with Hypoxic Respiratory Failure: Neurodevelopmental Follow-Up. Journal of Pediatrics 2007;150(3):235-240.
Christenson J, Singer J et al. A Clinical Prediction Rule For the Early Discharge of Patients With Chest pain. Annals of Emergency Medicine 2006;47,1: 1-10.
Cibere Singer J,et al. Urine CTX-II and urine C2C are differentially associated with radiographic and pre-radiographic knee osteoarthritis (OA): Results of a population-based study using MRI. Arthritis Rheum 2006;54:S160.
Kyriakides TC, Babiker A, Singer J, Piaseczny M, Russo, J on behalf of the OPTIMA Study Team. Study Conduct, Monitoring and Data Management in a Tri-National Trial: The OPTIMA Model. Clinical Trials 2004; 1,3: 277-281
The Canadian Early and Midtrimester Amniocentesis (CEMAT) Group. Prospective randomized clinical trial of early amniocentesis and midtrimester amniocentesis: Primary evaluation comparing procedure safety and fetal outcome. Lancet 1998; 351: 242-247.
Shafran S, Singer J, Zarowny DP, Phillips P, Salit I, Walmsley SL, et al . Rifabutin, ethambutol and clarithromycin versus rifampin, ethambutol, clofazimine and ciprofloxacin for Mycobacterium Avium Complex bacteremia: a prospective, randomized, multicenter, comparative trial (CTN 010) . New England Journal of Medicine 1996; 335:377-383.
Singer J, Thorne A, Khorasheh S, Raboud JM , Wu AW, Salit I, and Shafran SD for the CTN-010 Study Group. Symptomatic and Health Status Outcomes in the Canadian MAC Treatment Trial . International Journal of STD and AIDS 2000; 11:212-219.
Jaeschke R, Singer J, Guyatt GH. Ascertaining the minimal clincally important difference. Controlled Clinical Trials 1989; 10:407-415
Wilson DMC, Taylor DW, Gilbert JR, Best A, Lindsay EA, Willms DG, Singer J. A randomized trial of a family physician intervention for smoking cessation. Journal of the American Medical Association 1988; 260: 1570-1574.
Barrett BJ, Garg AX, Goeree R, Levin A, Molzahn A, Rigatto C, Singer J, Soltys G, Soroka S, Ayers D, Parfrey PS. A nurse-coordinatedbased model of care versus usual care for Stage 3/4 chronic kidney disease in the community: A randomized controlled trial. Clinical Journal of the American Society of Nephrology. June 2011 6: 1229-1231
I am involved in methodological aspects of trials in a variety of clinical areas including HIV, obstetrics, cardiology, health promotion and rheumatology.