The goal of my research program is to identify protein and amino acid (building blocks of protein) requirements during key life stages of growth and development, including pregnancy, childhood and malnutrition.
During pregnancy the nutritional state of the mother influences the rapidly growing fetus and affects long-term health. Due to ethical constraints protein requirements during pregnancy is not well studied. With the use of stable isotope tracers, which are completely safe for use in vulnerable populations like pregnant women, my research will measure requirements in the human body. The focus will be to make dietary protein and amino acid recommendations to improve long-term health for the mother and child.
Undernutrition or malnutrition has been implicated to be the underlying cause of ~50% of all deaths in children in the developing world. My research will examine the impact of childhood malnutrition on protein and amino acid requirements with collaborations between research institutes located in India and CFRI in Vancouver.
Elango R, Chapman K, Rafii M, Ball RO and Pencharz PB. Determination of the tolerable upper limit of leucine intake in young men. Am J Clin Nutr 2012; 96:759-67. PMID: 22952178
Elango R. Effects of Aging on Protein and Amino Acid Requirements. Amino Acid Research, (ISSN 1882 5001) Vol 5, No.2, 2011: 69-72.
Elango R, Humayun MA, Ball RO, Pencharz PB. Protein requirement of healthy school-age children determined by the indicator amino acid oxidation method. Am J Clin Nutr 2011 94: 6 1545-1552. PMID: 22049165
Pillai R, Elango R, Muthayya S, Ball RO, Kurpad AV and Pencharz PB. Lysine requirement of healthy, school-aged Indian children determined by the indicator amino acid oxidation technique. Journal of Nutrition 2010; 140: 54-59. PMID: 19923398
Elango R, Humayun MA, Ball RO and Pencharz PB. Evidence that protein requirements have been significantly underestimated. Current Opinion in Clinical Nutrition and Metabolic Care 2010; 13: 52-57. PMID: 19841581
Rafii M, Elango R, House JD, Courtney-Martin G, Fisher L, Darling P and Pencharz PB. Measurement of homocysteine and related metabolites in human plasma and urine by liquid chromatography electrospray tandem mass spectrometry. Journal of Chromatography B, 2009; 877: 3282-91. PMID: 19481985
Elango R, Humayun MA, Ball RO and Pencharz PB. Indicator amino acid oxidation is not affected by period of adaptation to a wide range of lysine intake in healthy young men. Journal of Nutrition 2009; 139: 1082-1087. PMID: 19369367
Elango R, Ball RO and Pencharz PB. Amino acid requirements in humans: with a special emphasis on metabolic availability of amino acids. Amino Acids 2009; 37: 19-27. PMID: 19156481
Pencharz PB, Elango R and Ball RO. An approach to defining the upper safe limits of amino acid intake. Journal of Nutrition 2008;138: 1996S-2002S. PMID: 18806114
Elango R, Ball RO and Pencharz PB. Indicator amino acid oxidation: concept and application. Journal of Nutrition 2008;138:243-246. PMID: 18203885
Elango R, Ball RO and Pencharz PB. Individual amino acid requirements in humans: an update. Current Opinion in Clinical Nutrition and Metabolic Care 2008;11:34-39. PMID: 18090656